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UID:153@womenshealthresearchcluster.com
DTSTART;TZID=America/Vancouver:20231023T090000
DTEND;TZID=America/Vancouver:20231023T103000
DTSTAMP:20250106T200910Z
URL:https://womenshealthresearchcluster.com/events/how-path-menopause-shap
 es-cardiovascular-disease-risk/
SUMMARY:How the path to menopause shapes cardiovascular disease risk
DESCRIPTION:\n\nSpeaker: Dr. Glen Pyle\, Professor of Molecular Cardio
 logy &amp\; Member of IMPART Network at Dalhousie Medicine\n\nGlen Pyle is
  a Professor of Molecular Cardiology and an Associate Member of the IMPART
  Network at Dalhousie Medicine. Dr. Pyle earned his PhD in Physiology and 
 Biophysics from the University of Tennessee Health Sciences Center followe
 d by an American Heart Association Post-Doctoral Fellowship at the Univers
 ity of Illinois at Chicago. The Pyle lab is currently interested in the se
 x differences associated with heart attacks\, including how menopause shap
 es the risk of post-heart attack mortality in women\, and the development 
 of novel therapies for heart attacks that are sex-specific.\n\nTalk summar
 y:\n\nFor much of their lives\, females have a lower cardiovascular diseas
 e risk profile than males\, but after menopause cardiovascular morbidity a
 nd mortality risk rises to match or even exceed levels of age-matched male
 s. While this risk phenomenon has been recognized for quite some time\, th
 e molecular mechanisms in the heart that contribute to the increased risk 
 are unknown. Cardiovascular symptoms in perimenopausal females like “hot
  flashes” suggest that changes in the cardiovascular system are establis
 hed before the onset of menopause\, but the lack of suitable animal models
  has prevented the investigation of this important transitional phase. Usi
 ng a unique mouse model in which a prolonged perimenopausal-like state pre
 cedes ovarian failure\, we have investigated a number of key risk factors 
 that evolve during perimenopause in the heart. We have also compared the p
 ost-menopausal state following a perimenopausal transition with the abrupt
  form of menopause brought about by surgical removal of the ovaries: a pat
 h to menopause that is associated with a higher risk of cardiovascular mor
 tality in females. Understanding the timing of cardiac changes that occur 
 in association with menopause is critical to identifying windows of risk a
 nd opportunity for therapeutic intervention\, while mechanisms of change a
 re critical for rationale therapeutic development.\n\nMentorship opportun
 ity: \n\nImmediately following Dr. Pyle's presentation\, audience member
 s will have the opportunity to hear more about Dr. Pyle's career. This i
 s an excellent opportunity for trainees to ask questions and learn more 
 about careers in women's health.\n\nAgenda:\n\n9-9:45 : Speaker presentati
 on\n\n9:45-10:00: Question and answer period\n\n10-10:30: Mentorship sessi
 on
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CATEGORIES:Women’s Health Seminar Series
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