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Mind the Gap: Hormonal Contraceptives and Brain Health

Do hormonal contraceptives influence brain health in women+?

Hormonal contraceptives (HC) are used by 850M girls, women and people with uteri—all reflected in the term women+—, and 16% of people (5-49y) in Canada. In addition to being contraceptives, HCs are prescribed off-label to treat many other conditions. Few studies have examined effects of these hormones on the brain, however recent work suggests they can increase risk for mood disorders during adolescence and alter brain activation patterns. Yet, how HC use may influence long-term brain health is not known.

Understanding brain health, especially through an equity lens, is critical. Women+ experience different brain health symptoms as a result of their unique experience of stress, which is impacted by age, gender, and race/ethnicity. Stress outcomes affect disease risk, which is also influenced by HCs. Collaborations between academics and research users is vital to understand the unique ways that women+’s lives impact their brain health. This conference explored how HCs influence women+’s brain health by bringing together researchers, clinicians, community partners, trainees, and policymakers to exchange knowledge and identify new research priorities that fill knowledge gaps and address patient experiences.

In this virtual conference series, we hosted bi-weekly events including two keynote talks, four symposia, trainee mentor sessions, guest workshops and a roundtable discussion where attendees co-created a blueprint for future research on hormonal contraceptives.

This virtual conference series dug into unique aspects of hormonal contraceptives and the examined effects of these hormones on the brain. It engaged researchers, clinicians, community partners, trainees, and policymakers to share research and develop strategies to spotlight the need for consideration of female-specific factors to improve women+’s brain health. The overall objective of this conference was to bring attention to the brain health issues that women+ face and encourage the medical, scientific and commercial communities to address them.

Conference Program

Date

Event

Speakers

Wednesday

October 5th, 2022

10AM – 11:15AM PDT

Session 1

Keynote Talk with Dr. Elizabeth Hampson

Opening conference remarks (10 minutes)

Program overview (10 minutes)

Keynote Talk: Dr. Elizabeth Hampson

  • An Introduction To Oral Contraceptives And Their Potential Effects In The Central Nervous System

Q&A (15 minutes)

Moderator: Dr. Liisa Galea, Lead Women’s Health Research Cluster

Keynote speaker: Dr. Elizabeth Hampson, University of Western Ontario, London, Ontario

Program Overview: Jesse Lacasse, PhD candidate, Concordia University

Wednesday

October 19th, 2022

10AM – 11 AM PDT

Session 2

Trainee-Mentor Networking Session with Dr. Lori Brotto

  • Communication Etiquette Within and Outside Academia
Moderator: Bonnie Lee, University of British Columbia

Mentor: Dr. Lori Brotto, University of British Columbia

Wednesday

October 26th, 2022

10AM – 11:45AM PDT

Session 3

Symposium 1: Imaging the Brain on Hormonal Contraceptives

  • Dr. Nafissa Ismail: The Effects of Pubertal Exposure to Oral Contraceptives on Brain Structure and Function
  • Dr. Caitlin Taylor: Striatal Dopamine Synthesis and Cognitive Flexibility Differ Between Hormonal Contraceptive Users and Non-user
  • Dr. Michael L. Lipton: OCP Effects on Hypothalamus: Clues and Limitations

Q&A (20-25 minutes)

Moderator: Dr. Nafissa Ismail, University of Ottawa, Ottawa, Ontario

Dr. Nafissa Ismail, University of Ottawa, Ottawa, Ontario

Dr. Caitlin Taylor, University of California (SB), Santa Barbara, California, USA.

Dr. Michael L. Lipton, Einstein College of Medicine, New York, USA.

Thursday

November 10th, 2022

10AM – 11AM PST

Session 4

Indigenous Women’s Health Session: Marisa Blake from Native Women’s Association of Canada

  • Iatrophobia and Medical Racism in Hormonal Birth Control: The Experiences of Indigenous Women, Girls, Two-Spirit, Transgender, and Gender-Diverse People in Canada
Moderator: Stephanie George, McMaster Univsersity

Marisa Blake, Native Women’s Association of Canada

Wednesday

November 23rd, 2022

10AM – 12:30PM PST

Session 5

Trainee Symposium

Trainee Poster Session: 10AM-11AM

  • Theme: Endogenous and Exogenous Hormones in Women+’s Health

Young Investigator Data Blitz: 11AM – 12:30PM

  • Jesse Lacasse: How ‘Androgenic’ Forms of Oral Contraceptives Alter Cognition in Women
  • Jennifer Williams: Heart-Brain Connection in Women: Contraceptive Hormones and the Peripheral Vasculature
  • Margot Morssinkhof: Differences in Insomnia and Depressive Symptoms in Oral Contraceptive Users and Non-Users
  • Laura Gravelsins: Hormonal Contraception and Cognition: Considering Genes and the Influence of Endogenous Ovarian Hormones for Clinical Translation
  • Rachel Gilfarb: Hormonal Contraceptive Exposure During Adolescence Impacts the Prefrontal Cortex and HPA Axis Response of Female Rats
Moderator: Katherine Moore, Women’s Health Research Cluster

Young Investigator Data Blitz speakers:

Jesse Lacasse, PhD candidate, Concordia University

Jennifer Williams, PhD candidate, McMaster University

Margot Morssinkhof, PhD student, Universiteit Amsterdam/ OLVG Hospital

Laura Gravelsins, PhD candidate, University of Toronto

Rachel Gilfarb, PhD candidate, Ohio State University

Wednesday

November 30th, 2022

10AM – 11:45AM PST

Session 6

Symposium 2: Hormonal Contraceptives Effects on Mental Health

  • Dr. Bronwyn Graham: The Impact of Hormonal Contraceptives on Anxiety Treatments: From Preclinical Models to Clinical Settings
  • Dr. Frances Chen: Adolescent Hormonal Contraceptive Use and Long-Term Risk for Depression
  • Dr. Natalie Tronson: TBD

Q&A (20-25 minutes)

Moderator: Dr. Frances Chen, University of British Columbia, Vancouver, BC.

Dr. Bronwyn Graham, University of New South Wales, Sydney, Australia.

Dr. Frances Chen, University of British Columbia, Vancouver, BC.

Dr. Natalie Tronson, University of Michigan, Ann Arbor, Michigan, USA

Friday

December 9th, 2022

10AM -11 AM PST

Session 7

Trainee-Mentor Networking Session with Dr. Angela Kaida

  • Global Health and Interdisciplinary Research
Moderators: Bonnie Lee, University of British Columbia & Dr. Sonja Senthanar, University of British Columbia

Mentor: Dr. Angela Kaida, Simon Fraser University

Tuesday

January 17th, 2023

10AM – 11AM PST

Session 8

Workshop: Gender and Hormonal Contraceptives

  • Dr. Adriene Beltz: Assessing the Psychological Correlates of Hormonal Contraceptive Use in Unique Women: A Workshop on Study Design
Moderator: Jennifer Williams, McMaster University

Dr. Robert-Paul Juster, University of Montreal

Dr. Adriene Beltz, University of Michigan, Ann Arbor, Michigan

Thursday

January 26th, 2023

10AM – 11:45AM PST

Session 9

Symposium 3: Hormonal Contraceptives and Risks for Women’s Health

  • Dr. Ami Pravinkant Raval: Oral Contraceptives and Stroke: Foes or friends
  • Dr. Kelly Klump: Combined Oral Contraceptive Use and Binge Eating Women: Potential gene x Hormone Interactions
  • Dr. Sofia Ahmed: TBD

Q&A (20-25 minutes)

Moderator: Maureen MacDonald, McMaster University

Dr. Ami Pravinkant Raval, University of Miami, Florida, USA

Dr. Kelly Klump, Michigan State University, East Lansing, Michigan, USA.

Dr. Sofia Ahmed, University of Calgary, Calgary, Alberta.

Wednesday

February 1st, 2023

10AM – 11PM PST

Session 10

Trainee-Mentor Networking Session with Dr. Liisa Galea

  • Beyond SGBA: Women’s Health
Moderators: Bonnie Lee, University of British Columbia & Dr. Hashim Islam, University of British Columbia Okanagan

Mentor: Dr. Liisa Galea, University of British Columbia

Thursday

February 9th, 2023

11AM – 12PM PST

Session 11 

Workshop on Brain Imaging Studies

Moderator: Alexandra Ycaza Herrera, University of Southern California

Dr. Nicole Petersen, University of California (Irvine), Irvine, California, USA.

Dr. Caitlin Taylor, University of California (SB), Santa Barbara, California, USA.

Thursday

February 23rd, 2023

10AM – 11AM PST

Session 12

Workshop on Animal Models

Moderator: Jesse Lacasse, PhD candidate, Concordia University

Jesse Lacasse, PhD candidate, Concordia University

Dr. Natalie Tronson, University of Michigan, Ann Arbor, Michigan, USA

Wednesday

March 1st, 2023

10AM – 11AM PST

Session 13

Trainee-Mentor Networking Session with Harlan Pruden

  • Ending Anti-Indigenous Racism in Research and the Academy
Moderators: Bonnie Lee, University of British Columbia & Parisa Alaei, University of British Columbia Okanagan

Mentor: Harlan Pruden, BC Centre for Disease Control

Wednesday

March 8th, 2023

10AM – 11AM PST

Session 14

Discussion with Dr. Sarah E. Hill, author of “This is Your Brain on Birth Control”

Moderator: Bonnie Lee, University of British Columbia

Dr. Sarah E. Hill, Texas Christian University, Texas, USA.

Thursday,

March 23rd, 2023

10AM – 11:45AM PDT

Session 15

Symposium 4: Hormonal Contraceptives and Cognition

  • Dr. Adriene Beltz: From General Inferences to Specific Effects: Evaluating Research on Hormonal Contraceptives and Cognition
  • Dr. Birgit Derntl: Empathy, Stress and so Much More: Hormonal Contraception and the Social Brain
  • Dr. Marie-France Marin: Current and Lasting Effects of Oral Contraceptive Use on Emotional, Cognitive, and Brain Functions

Q&A (20-25 minutes)

Moderator: Dr. Gillian Eintstein, University of Toronto

Dr. Adriene Beltz, University of Michigan, Ann Arbor, Michigan

Dr. Birgit Derntl, University of Tübingen, Germany

Dr. Marie-France Marin, University of Quebec, University of Montreal

Thursday

March 30th, 2023

10AM – 12PM PDT

Session 16

Round Table Discussion

  • Discussion topic: Building a Blueprint for Future Research on Hormonal Contraceptives and Women’s Health

Trainee poster award ceremony and closing remarks from Dr. Liisa Galea (15 minutes)

Planning Committee

  • Dr. Liisa Galea
  • Dr. Sofia Ahmed
  • Dr. Frances Chen
  • Dr. Gillian Einstein
  • Elizabeth Hampson
  • Nafissa Ismail
  • Jesse Lacasse
  • Dr. Maureen MacDonald
  • Jennifer Williams
  • Katherine Moore
  • Bonnie Lee

Partners and Sponsors

This conference was made possible by support from the Canadian Institutes of Health Research, the Elsevier Publishing company and the University of British Columbia Work Learn program. The Trainee Mentor Sessions were brought to you through our partnership with the Institute of Gender and Health Trainee Network. We are deeply grateful for the support of these organizations and everyone who donates to the Women’s Health Research Cluster.

                

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